// Signal Intelligence for Human Health

Your health has a voice.
Now it can be heard.

Your wearable tracks your body. Your voice carries your story.
For the first time, both are understood — together.

A continuous monitoring platform that detects early physiological change by combining voice and vital signs over time.

The standard is shifting — from snapshots to continuous signals.
<30s
Clinical insights
review-to-decision time
350+
Patients across
clinical studies
7
Countries with active
commitments to evaluate platform

Two signals.
One clinical picture.

Step 01 /
Passive monitoring begins immediately
Patients use devices they already own. Akouō integrates with Apple Watch, Oura, Garmin, Whoop, Samsung, and more — continuously streaming vitals with zero new hardware procurement.
Step 02 /
Voice is captured at any touchpoint
Short recordings during check-ins, telehealth visits, or through the Akouō Health app generate acoustic and linguistic signal profiles. No scripted tasks. No clinical staff time required.
Step 03 /
Clinicians receive a 30-second summary
OpenDx™ fuses vitals, acoustic and linguistic signals, metabolic data, and health history — surfacing early physiological shifts in a structured clinical report designed for point-of-care interpretation.

See change earlier — before it becomes a diagnosis.

Across conditions. Across care settings.

Most clinical deterioration doesn't begin with a diagnosis.
It begins with subtle shifts:

Rising respiratory rate
Changes in sleep and heart rate variability
Reduced vocal energy or coherence

Akouō continuously analyzes these signals — helping clinicians recognize change earlier, across conditions.

From early infection → to chronic instability → to post-discharge decline
Akouō surfaces the same thing: change from baseline.

Initially focused on early detection of clinical deterioration in high-risk patients — including CHF, COPD, and post-acute care settings.

// Evidence

Validated in real-world clinical settings.

The underlying models have demonstrated strong performance in early clinical studies — identifying patterns of physiological change associated with acute deterioration.

Tested across emergency and acute care environments, with ongoing validation across chronic and longitudinal care settings.

Early clinical evaluation demonstrated high sensitivity (98%) for identifying patients with confirmed sepsis — validating the model's ability to detect early physiological change.

Health data is increasing.
Data interpretation has to keep up.

Most changes in health begin quietly — in how you feel, how you speak, and how your body responds over time.

These signals exist. They've always existed. They've just never been connected.

Akouō Health™ defines a new class of platform — unifying voice and vital signals into a single clinical picture.
// Signal streams
Heart Rate
72 bpm
Resp. Rate
16 /min
Temperature
36.8°C
SpO₂
97%

Vitals + Voice
→ A new signal in healthcare

A first-of-its-kind approach to understanding early change — built for real-world care.

01 /
Signal Fusion
The first system to unify wearable data and the human voice into a single bio signal intelligence layer — detecting early shifts in physiological state through continuous, passive monitoring.
02 /
Designed for real-world practice
No new hardware. No workflow disruption. Integrates with the devices patients already use — including Apple Watch, Oura Ring, Garmin, Whoop, Fitbit, and more.
03 /
Built for real care
Designed so clinicians can recognize meaningful changes quickly — without added complexity, new infrastructure, or EHR dependency.
Powered by OpenDx™ — a multimodal intelligence engine built for real-world care.

A clinical intelligence platform.
Beyond wearable apps.

Insights by Akouō Health™ is a passive, always-on monitoring system that ingests data from devices patients already own, fuses it with acoustic and linguistic signal analysis through the OpenDx™ Core Engine, and delivers structured clinical summaries — designed for 30-second interpretation at the point of care.

This is not a consumer wellness app. It's a continuous monitoring platform built for clinical practices and care teams that need early signals — without adding manual data review to their workflow.

Primary User
Physicians & Care Teams
Designed for physicians and care teams managing patients between visits — including outpatient clinicians and remote monitoring programs. Surfaces early signals of change without adding dashboard burden — built for rapid, ~30-second review with no new training required.
Primary Buyer
Clinical Practice Leaders
& Care Delivery Innovators
Built for clinical practices seeking to reduce avoidable escalations, improve outcomes, and generate measurable ROI from continuous monitoring.
Clinical Operations
RPM Program Directors
Supercharge your existing remote monitoring program with multimodal signal fusion — without replacing your current infrastructure. Compatible with CMS RPM billing codes (CPT 99453, 99454, 99457).

From passive signals
to actionable insight — within seconds.

The OpenDx™ Core Engine continuously ingests multimodal patient data, applies AI-driven fusion and pattern detection, and delivers structured clinical summaries through the Insights dashboard.

Detects early physiologic changes — such as rising respiratory rate, subtle vocal fatigue, and reduced lexical coherence — before traditional thresholds are crossed.

// Data Inputs
Vitals from any wearable
HR, SpO₂, HRV, temp, sleep, activity
🎙️
Acoustic, prosodic, and linguistic features from voice
Spectral features, perturbation (jitter/shimmer), temporal dynamics, and lexical patterns
📊
Continuous Metabolic Monitoring
CGM data, glucose trends, HbA1c proxies
📋
Health History
Diagnoses, medications, risk factors
// Core Processing
AI
OpenDx™
Core Engine
1
Data Fusion
2
Pattern Mapping
// Clinical Output
Insights by Akouō Health™
Clinician-facing intelligence dashboard
Akouō insights
Time-synchronized patterns
Annotate ∨
Voice features of interest
Observational signals — not diagnostic
Annotate ∨
Time-aligned insights
Temporal relationships across data streams
24h | Jan 12
120600
⏱ 10:00 HR (BPM)85 RR (BR/MIN)18 SPO2 (%)97 TEMP (°C)37.1
08:00 10:00 12:00 14:00
HR
Resp.
SpO₂
Temp
Voice event
A unified intelligence layer — wearable vitals + acoustic and linguistic signals + metabolic data + health history — continuously fused, continuously monitored.

Built for the way clinicians
actually work.

Akouō Health sits at the intersection of remote patient monitoring and clinical decision support — surfacing signal where it matters most, without adding workflow burden.

Reviewed during routine check-ins, between visits, or triggered by early signal changes.

Step 01 /
Passive Enrollment
Patients enroll using devices they already own. No new hardware requirements. The platform begins continuous, passive data collection immediately — no active input needed from the patient beyond natural speech.
Step 02 /
Continuous Signal Fusion
The OpenDx™ Core Engine runs 24/7 in the background — fusing wearable vitals, acoustic and linguistic signals, metabolic data, and health history into a unified physiological state model for each patient.
Step 03 /
Clinician-Ready Alerts
When the system detects an early physiological shift, clinicians receive a structured 30-second summary in the Insights dashboard — actionable, prioritized, and ready for documentation workflows.
The Problem We Solve

Patients deteriorate between visits. Current tools don't connect the dots.

Traditional remote monitoring captures single signals in isolation. No existing system combines vocal health data with physiological wearable data and metabolic monitoring — leaving a vast, unexplored signal space invisible to clinicians. Enables earlier intervention without increasing clinician workload.

The Akouō Difference
Detects subtle deterioration days earlier through multimodal signal fusion
Reduces avoidable readmissions through early intervention signals
Integrates into existing RPM and EHR workflows with zero added friction
Scales across chronic disease populations with measurable operational ROI

Built on clinical research.
Tested in real-world care.

Akouō Health™ is grounded in established research across physiology, speech analysis, and early clinical deterioration.

Its underlying models have been evaluated in real-world hospital environments, demonstrating strong performance in identifying patients with confirmed sepsis during early-stage assessment.

Early clinical evaluation demonstrated high sensitivity (98%) for identifying patients with confirmed sepsis — validating the model's ability to detect early physiological change.

Clinical Evaluation
Tested in challenged, acute care settings where early recognition is critical and time-to-insight is measured in minutes, not hours.
Multimodal Research Foundation
Built on peer-reviewed domains including vital signs, acoustic and linguistic signals, and time-series analysis — voice and wearables combined with AI.
Voice + Vitals = Unexplored Signal Density
Physician-Guided Development
Designed in collaboration with clinicians across critical care, emergency medicine, and global health systems.
This is not theoretical. It is already being studied, validated, and applied in real-world care.

Built with leading institutions.
Recognized for innovation.

Research & Validation Partners
Mayo Clinic
Red de Salud UC CHRISTUS
Built alongside clinicians.
Expanding across global care settings.
Recognition
2025
NCTECH AI, ML & Data Innovation Company of the Year
2025
F6S Top 40 AI Company in the United States
2025
NCTECH State of Tech Startup Showcase Winner
2024
Coastal Entrepreneur of the Year
2024
NC Biotech Venture Challenge — Top 3

Built by clinicians, engineers,
and signal scientists.

Morris Nguyen, MD, MBA
Founder & CEO
Kathryn Roberts
Chief Operating Officer
Ryan Roberts
Chief Technology Officer
Dana Xiadani
Head of Speech Engineering & Intelligence
Gerald Maccioli, MD, MBA
Chief Strategy Officer
Sunil Desai, MD, FCCP
Chief Medical Officer
Bridging clinical medicine, AI, and human signal understanding.
// Akouō Health™

Because when it comes to health,
silence isn't safe.

The standard is shifting — from snapshots to continuous signals.
Observe.
Wearable + Voice
·
Understand.
OpenDx™ Intelligence
·
Act.
Clinician, hours earlier

Now onboarding early clinicians, partners, and patients.